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Article

p16INK4a-induced senescence is disabled by melanoma-associated mutations.

Aging cell - 1 Oct 2008

Haferkamp Sebastian, Becker Therese M, Scurr Lyndee L, Kefford Richard F, Rizos Helen

Abstract excerpt

The p16(INK4a)-Rb tumour suppressor pathway is required for the initiation and maintenance of cellular senescence, a state of permanent growth arrest that acts as a natural barrier against cancer progression. Senescence can be overcome if the pathway is not fully engaged, and this may occur when p16(INK4a) is inactivated. p16(INK4a) is frequently altered in human cancer and germline mutations affecting p16(INK4a)...

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Source

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Identifiers

PMID: 18843795
DOI: 10.1111/j.1474-9726.2008.00422.x
PMCID: PMC2582406

Genes

CDK4
CDK2
CDK6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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