Article
Cardiac Characteristics of Transgenic Mice Overexpressing Refsum Disease Gene-Associated Protein within the Heart.
Biochemical and biophysical research communications - 7 Sept 2001
Koh J T, Choi H H, Ahn K Y, Kim J U, Kim J H, Chun J Y, Baik Y H, Kim K K
Abstract excerpt
Arrhythmia is a common cardiac symptom of Refsum disease. Recently, we identified a novel neuron-specific PAHX-associated protein (PAHX-AP1), which binds to the Refsum disease gene (PAHX). In this report, we developed heart-targeted transgenic (TG) mice under the control of alpha-myosin heavy chain promoter to determine whether cardiac overexpression of PAHX-AP1 provokes cardiac involvement symptoms. Northern and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.