[Application of transgenic animal in hypertrophic cardiomyopathy].

Abstract excerpt

Hypertrophic cardiomyopathy is an autosomal-dominant disease. Disease-causing mutations have been found in genes encoding structural components of the thick and thin filament systems of cardiac myocyte; it has therefore been named as a disease of sarcomere. Many approaches have been used to characterize the pathogenesis of the disease. Transgenic animal models have been created to gain further insight into the...

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