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Article

Phenotypical features of long Q-T syndrome in transgenic mice expressing human Na-K-ATPase alpha(3)-isoform in hearts.

American journal of physiology. Heart and circulatory physiology - 1 Nov 2000

O'Brien S E, Apkon M, Berul C I, Patel H T, Saupe K, Spindler M, Ingwall J S, Zahler R

Abstract excerpt

To understand why the adult human heart expresses three isoforms of the sodium pump, we generated transgenic mice (TGM) with 2.3- to 5. 5-fold overexpression of the human alpha(3)-isoform of Na-K-ATPase in the heart. Hearts from the TGM had increased maximal Na-K-ATPase activity and ouabain affinity compared with control hearts, even though the density of Na-K-ATPase pump sites (of all isoforms) was similar to...

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Identifiers

PMID: 11045946
DOI: 10.1152/ajpheart.2000.279.5.H2133

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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