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Article

Changes underlying arrhythmia in the transgenic heart overexpressing Refsum disease gene-associated protein.

Biochemical and biophysical research communications - 2 Jan 2004

Koh Jeong Tae, Jeong Byung Chul, Kim Jae Ha, Ahn Young Keun, Lee Hyang Sim, Baik Yung Hong, Kim Kyung Keun

Abstract excerpt

Previously, we identified a novel neuron-specific protein (PAHX-AP1) that binds to Refsum disease gene product (PAHX), and we developed transgenic (TG) mice that overexpress heart-targeted PAHX-AP1. These mice have atrial tachycardia and increased susceptibility to aconitine-induced arrhythmia. This study was undertaken to elucidate the possible changes in ion channels underlying the susceptibility to arrhythmia...

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Source

Identifiers

PMID: 14672712
DOI: 10.1016/j.bbrc.2003.11.105

Genes

ADRB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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