Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polyomavirus large T-antigen expression in heart of transgenic mice causes cardiomyopathy.

Oncogene - 1 Nov 1990

Chalifour L E, Gomes M L, Wang N S, Mes-Masson A M

Abstract excerpt

One of the early genes of polyomavirus, large T-antigen (PVLT), has been classified in vitro as an immortalizing gene. In order to determine the ability of PVLT to cause the formation of hyperplasia or tumors in vivo, we generated transgenic mice harboring the cDNA for PVLT linked to the heavy-metal responsive metallothionein-1 promoter (MT). The transgene was primarily expressed in testes and seminal vesicles,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Gene Expression
Share to Immunohistochemistry

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Inbred BALB C

Share to Mice, Inbred C57BL

Share to Mice, Transgenic

Share to Molecular Sequence Data

Source

Identifiers

PMID: 2176284

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polyomavirus large T-antigen expression in heart of transgenic mice causes cardiomyopathy.PMID 2176284Read ↗

Conditional Expression of SV40 T-antigen in Mouse Cardiomyocytes Facilitates an Inducible Switch from Proliferation to DifferentiationSemantic proximity Read ↗

Increased susceptibility to structural acute kidney injury in a mouse model of presymptomatic cardiomyopathy.Semantic proximity Read ↗

Mitochondrial DNA mutations activate programmed cell survival in the mouse heart.Semantic proximity Read ↗

Merkel Cell Polyomavirus Small T Antigen Is Oncogenic in Transgenic MiceSemantic proximity Read ↗

Transgenic hepatocarcinogenesis in the rat.Semantic proximity Read ↗

Conditional liver-specific expression of simian virus 40 T antigen leads to regulatable development of hepatic neoplasm in transgenic mice.Semantic proximity Read ↗

Human myocardial cell lines generated with SV40 temperature-sensitive mutant tsA58.Semantic proximity Read ↗

Morphological, histochemical, immunohistochemical, and ultrastructural characterization of tumors and dysplastic and non-neoplastic lesions arising in BK virus/tat transgenic mice.Semantic proximity Read ↗

Pulmonary carcinogenesis in transgenic mice.Semantic proximity Read ↗

Targeted expression of SV40 T antigen in the hair follicle of transgenic mice produces an aberrant hair phenotype.Semantic proximity Read ↗

An activated allele of the c-erbB-2 oncogene impairs kidney and lung function and causes early death of transgenic mice.Semantic proximity Read ↗

Construction of transgenic mice with tissue-specific acceleration of mitochondrial DNA mutagenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.