Article
Polyomavirus large T-antigen expression in heart of transgenic mice causes cardiomyopathy.
Oncogene - 1 Nov 1990
Chalifour L E, Gomes M L, Wang N S, Mes-Masson A M
Abstract excerpt
One of the early genes of polyomavirus, large T-antigen (PVLT), has been classified in vitro as an immortalizing gene. In order to determine the ability of PVLT to cause the formation of hyperplasia or tumors in vivo, we generated transgenic mice harboring the cDNA for PVLT linked to the heavy-me...
Topics
- Animals
- Antigens, Viral, Tumor
- Base Sequence
- Cardiomyopathy, Dilated
- DNA, Recombinant
- Gene Expression
- Immunohistochemistry
- Kidney
- Male
- Metallothionein
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Mice, Transgenic
- Microscopy, Electron
- Molecular Sequence Data
- Myocardium
- Organ Size