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Article

PQBP-1 transgenic mice show a late-onset motor neuron disease-like phenotype.

Human molecular genetics - 1 Apr 2003

Okuda Tomohiro, Hattori Hiroshi, Takeuchi Sousuke, Shimizu Jun, Ueda Hiroko, Palvimo Jorma J, Kanazawa Ichiro, Kawano Hitoshi, Nakagawa Masaya, Okazawa Hitoshi

Abstract excerpt

A body of experimental evidence indicates that transcription and/or mRNA processing factors interacting with the polyglutamine disease gene products play crucial roles in the pathology. PQBP-1 is one of these factors and it has been shown to interact with the spinocerebellar ataxia type-1 (SCA1) disease gene product, ataxin-1. Our previous data suggested that relatively high expression of PQBP-1 in the cerebellum...

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PMID: 12651867
DOI: 10.1093/hmg/ddg084

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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