Article
Altered function in atrium of transgenic mice overexpressing triadin 1.
American journal of physiology. Heart and circulatory physiology - 1 Oct 2002
Kirchhefer Uwe, Baba Hideo A, Kobayashi Yvonne M, Jones Larry R, Schmitz Wilhelm, Neumann Joachim
Abstract excerpt
Triadin 1 is a protein in the cardiac junctional sarcoplasmic reticulum (SR) that interacts with the ryanodine receptor, junctin, and calsequestrin, proteins that are important for Ca(2+) release. To better understand the role of triadin 1 in SR-Ca(2+) release, we studied the time-dependent expression of SR proteins and contractility in atria of 3-, 6-, and 18-wk-old transgenic mice overexpressing canine cardiac...
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