Article
Transgenic mice carrying the human beta 2-adrenergic receptor gene with its own promoter overexpress beta 2-adrenergic receptors in liver.
European journal of biochemistry - 15 Oct 1996
André C, Erraji L, Gaston J, Grimber G, Briand P, Guillet J G
Abstract excerpt
Up to now, transgenic mice models created to study the physiological impact of alterations in the human beta-adrenoceptor system have only focused on cardiac tissues and carried hybrid transgenes with strong cardiac promoters. We have developed a transgenic mouse strain (F28) carrying the human b...
Topics
- Adenylyl Cyclases
- Animals
- Base Sequence
- DNA Probes
- Female
- GTP-Binding Proteins
- Gene Expression
- Humans
- Iodocyanopindolol
- Isoproterenol
- Liver
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Inbred DBA
- Mice, Transgenic
- Phenotype
- Pindolol