Article
Hypertension in transgenic mice with brain-selective overexpression of the alpha(2B)-adrenoceptor.
American journal of hypertension - 1 Jan 2009
Kintsurashvili Ekaterina, Shenouda Sherene, Ona Deborah, Ona Leonardo, Ahmad Saad, Ravid Katya, Gavras Irene, Gavras Haralambos
Abstract excerpt
BACKGROUND: Previous studies have shown that the presynaptic alpha(2B)-adrenoceptor subtype in the central nervous system has a sympathoexcitatory function and its activation leads to a hyperadrenergic hypertensive state. The purpose of this project was to develop a novel hyperadrenergic model, a transgenic (TG) mouse model with brain-selective overexpression of the alpha(2B)-adrenergic receptor (alpha(2B)-AR)....
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