Article
Pathophysiological remodeling of mouse cardiac myocytes expressing dominant negative mutant of neuron restrictive silencing factor.
Circulation journal : official journal of the Japanese Circulation Society - 1 Nov 2010
Takano Makoto, Kinoshita Hideyuki, Shioya Takao, Itoh Masayuki, Nakao Kazuwa, Kuwahara Koichiro
Abstract excerpt
BACKGROUND: It has been previously reported that the transgenic mouse expressing the dominant negative mutant of the neuron restrictive silencing factor (dnNRSF) in the heart died from lethal arrhythmia, so the present study aimed to clarify the electrophysiological alteration of the ventricular myocyte isolated from the dnNRSF mouse. METHODS AND RESULTS: The action potential (AP) and membrane currents were...
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