Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Regionalized neurofilament accumulation and motoneuron degeneration are linked phenotypes in wobbler neuromuscular disease.

Neurobiology of disease - 1 Aug 2001

Pernas-Alonso R, Perrone-Capano C, Volpicelli F, di Porzio U

Abstract excerpt

Abnormal neurofilament aggregates are pathological hall-mark of most neurodegenerative diseases, although their pathogenic role remains unclear. Increased expression of medium neurofilament (NFM) is an early molecular marker of wobbler mouse, an animal model of motoneuron disease. In the wr/wr, a vacuolar neuronal degeneration (VND) starts at 15 days postnatally, selectively in cervical spinal cord and brain stem...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Dosage
Share to Homeostasis
Share to Mice, Inbred Strains

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Neurologic Mutants

Share to Motor Neurons

Share to Nerve Degeneration

Share to Neurofilament Proteins

Share to Neuromuscular Diseases

Source

Identifiers

PMID: 11493023
DOI: 10.1006/nbdi.2001.0403

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regionalized neurofilament accumulation and motoneuron degeneration are linked phenotypes in wobbler neuromuscular disease.PMID 11493023Read ↗

The mouse mutation muscle deficient (mdf) is characterized by a progressive motoneuron disease.Semantic proximity Read ↗

Neurofilament homeostasis and motoneurone degenerationSemantic proximity Read ↗

Genetic modifiers that aggravate the neurological phenotype of the wobbler mouse.Semantic proximity Read ↗

Spatiotemporal progression of neurodegeneration and glia activation in the wobbler neuropathy of the mouse.Semantic proximity Read ↗

Wobbler, a mutation affecting motoneuron survival and gonadal functions in the mouse, maps to proximal chromosome 11.Semantic proximity Read ↗

Reduced branching and length of dendrites detected in cervical spinal cord motoneurons of Wobbler mouse, a model for inherited motoneuron disease.Semantic proximity Read ↗

Age-related axonal and myelin changes in the rumpshaker mutation of the Plp gene.Semantic proximity Read ↗

A novel behavioral method to detect motoneuron disease in Wobbler mice aged three to seven days old.Semantic proximity Read ↗

The Wlds mutation delays robust loss of motor and sensory axons in a genetic model for myelin-related axonopathy.Semantic proximity Read ↗

Spinal muscular atrophy gene wobbler of the mouse: evidence from chimeric spinal cord and testis for cell-autonomous function.Semantic proximity Read ↗

Neurobehavioral characteristics of mice with modified intermediate filament genes.Semantic proximity Read ↗

Progressive loss of motor neuron function in wasted mice: effects of a spontaneous null mutation in the gene for the eEF1 A2 translation factor.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.