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Article

Age-related axonal and myelin changes in the rumpshaker mutation of the Plp gene.

Acta neuropathologica - 1 Apr 2004

Edgar J M, McLaughlin M, Barrie J A, McCulloch M C, Garbern J, Griffiths I R

Abstract excerpt

The PLP1/Plp gene encodes proteolipid protein (PLP) and DM20, the major central nervous system myelin proteins. Mutations in the PLP1/ Plp gene cause dysmyelinating disorders in man and animals. The rumpshaker mutation was first identified in mice and later linked to a family diagnosed with neurological deficits akin to spastic paraplegia. The dysmyelination in the young rumpshaker mouse is well characterised....

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Source

Identifiers

PMID: 14745569
DOI: 10.1007/s00401-003-0808-9

Genes

PLP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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