Article
A novel behavioral method to detect motoneuron disease in Wobbler mice aged three to seven days old.
Brain research - 7 Dec 1998
Bose P, Fielding R, Ameis K M, Vacca-Galloway L L
Abstract excerpt
The Wobbler mouse possesses an inherited autosomal recessive form of motoneuron disease. The most characteristic abnormality is the degeneration of motoneurons, mostly in the cervical spinal cord, and in the brain stem cranial motor nuclei. The underlying pathology shows up as symptoms that are o...
Topics
- Age Factors
- Animals
- Behavior, Animal
- Body Weight
- Logistic Models
- Mice
- Mice, Inbred C57BL
- Mice, Neurologic Mutants
- Motor Neuron Disease
- Nerve Degeneration
- Phenotype
- Reflex, Abnormal