Article
Spinal muscular atrophy gene wobbler of the mouse: evidence from chimeric spinal cord and testis for cell-autonomous function.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Jul 1997
Augustin M, Heimann P, Rathke S, Jockusch H
Abstract excerpt
Human hereditary neurodegenerative diseases are genetically and mechanistically very heterogeneous and so are spinal muscular atrophies and cerebellar ataxias in the mouse, despite the common phenomenon of neuronal death. In this species, a number of mutations impair spermiogenesis in addition to...
Topics
- Animals
- Chimera
- Female
- Gliosis
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Inbred NZB
- Mice, Neurologic Mutants
- Microscopy, Confocal
- Microscopy, Electron
- Muscular Atrophy, Spinal
- Mutation
- Polymerase Chain Reaction
- RNA, Messenger
- Receptors, Cholinergic
- Spermatogenesis
- Spinal Cord