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Article

Progressive loss of motor neuron function in wasted mice: effects of a spontaneous null mutation in the gene for the eEF1 A2 translation factor.

Journal of neuropathology and experimental neurology - 1 Apr 2005

Newbery Helen J, Gillingwater Thomas H, Dharmasaroja Permphan, Peters Josephine, Wharton Stephen B, Thomson Derek, Ribchester Richard R, Abbott Catherine M

Abstract excerpt

Wasted (wst) is a spontaneous autosomal recessive mutation in which the gene encoding translation factor eEF1A2 is deleted. Homozygous mice show tremors and disturbances of gait shortly after weaning, followed by motor neuron degeneration, paralysis, and death by about 28 days. We have now conduc...

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Identifiers

PMID: 15835265
DOI: 10.1093/jnen/64.4.295

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15835265-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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