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Article

Neurofilament homeostasis and motoneurone degeneration

21 Dec 2000

Abstract excerpt

Neurofilament disorganisation is a hallmark of various neurodegenerative diseases. We review here current knowledge of neurofilament structure, gene expression and function. Neurofilament involvement in motoneurone neurological diseases is discussed in view of recent data from transgenic and spontaneous mouse mutants. In the mammalian neurone, the three neurofilament subunits are assembled into intermediate...

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PMID: 11135306
DOI: 10.1002/1521-1878(200101)23:1<24::aid-bies1004>3.0.co;2-h

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