The mouse mutation muscle deficient (mdf) is characterized by a progressive motoneuron disease.

Abstract excerpt

Muscle deficient (mdf) is an autosomal-recessive mutation mapped to mouse chromosome 19. The clinical phenotype and the muscle histopathology, briefly described in 1980, and the nervous system histopathology are detailed in the present study. Homozygotes develop a posterior waddle at 4 to 8 weeks...

Topics

• Animals
• Disease Models, Animal
• Electrophysiology
• Mice
• Motor Neuron Disease
• Muscle Fibers, Skeletal
• Muscle, Skeletal
• Mutation
• Sciatic Nerve
• Spinal Cord