Article
Wobbler, a mutation affecting motoneuron survival and gonadal functions in the mouse, maps to proximal chromosome 11.
Genomics - 1 May 1992
Kaupmann K, Simon-Chazottes D, Guénet J L, Jockusch H
Abstract excerpt
The wobbler mouse (genotype wr/wr) has been considered as an animal model for human neurodegenerative disorders. In the homozygous condition, the autosomal mutation wobbler (wr) causes a motoneuron disease and gonadal dysfunction. We have genetically mapped the wr gene, using an interspecific bac...
Topics
- Animals
- Chromosome Mapping
- Crosses, Genetic
- Disease Models, Animal
- Genetic Linkage
- Genetic Markers
- Mice
- Mice, Inbred C57BL
- Mice, Neurologic Mutants
- Motor Neuron Disease
- Muridae
- Mutation
- Phenotype
- Polymorphism, Restriction Fragment Length