Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Wobbler, a mutation affecting motoneuron survival and gonadal functions in the mouse, maps to proximal chromosome 11.

Genomics - 1 May 1992

Kaupmann K, Simon-Chazottes D, Guénet J L, Jockusch H

Abstract excerpt

The wobbler mouse (genotype wr/wr) has been considered as an animal model for human neurodegenerative disorders. In the homozygous condition, the autosomal mutation wobbler (wr) causes a motoneuron disease and gonadal dysfunction. We have genetically mapped the wr gene, using an interspecific backcross between the laboratory strain C57BL/6J (wr/+) and Mus spretus. The expected percentage of wobbler progeny were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosome Mapping
Share to Genetic Linkage
Share to Genetic Markers

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Inbred C57BL

Share to Mutation

Share to Phenotype

Share to Polymorphism, Restriction Fragment Length

Source

Identifiers

PMID: 1349581
DOI: 10.1016/0888-7543(92)90199-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Wobbler, a mutation affecting motoneuron survival and gonadal functions in the mouse, maps to proximal chromosome 11.PMID 1349581Read ↗

Genetic modifiers that aggravate the neurological phenotype of the wobbler mouse.Semantic proximity Read ↗

Spinal muscular atrophy gene wobbler of the mouse: evidence from chimeric spinal cord and testis for cell-autonomous function.Semantic proximity Read ↗

The wobbler mouse: a neurodegeneration jigsaw puzzle.Semantic proximity Read ↗

Human homologue of a gene mutated in the slow Wallerian degeneration (C57BL/Wld(s)) mouse.Semantic proximity Read ↗

Genetic transfer of the wobbler gene to a C57BL/6J x NZB hybrid stock: natural history of the motor neuron disease and response to CNTF and BDNF cotreatment.Semantic proximity Read ↗

Interspecific backcross mice show sex-specific differences in allelic inheritance.Semantic proximity Read ↗

Implementation of a manual for working with wobbler mice and criteria for discontinuation of the experiment.Semantic proximity Read ↗

Regionalized neurofilament accumulation and motoneuron degeneration are linked phenotypes in wobbler neuromuscular disease.Semantic proximity Read ↗

Sex-restricted non-Mendelian inheritance of mouse chromosome 11 in the offspring of crosses between C57BL/6J and (C57BL/6J x DBA/2J)F1 mice.Semantic proximity Read ↗

WHIRLER MICE: A RECESSIVE BEHAVIOR MUTATION IN LINKAGE GROUP VIII.Semantic proximity Read ↗

Physical mapping of the Tec and Gabrb1 loci reveals that the Wsh mutation on mouse chromosome 5 is associated with an inversion.Semantic proximity Read ↗

Fine genetic and comparative mapping of the deafness mutation Ames waltzer on mouse chromosome 10.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.