Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss of mismatch repair activity in simian virus 40 large T antigen-immortalized BPH-1 human prostatic epithelial cell line.

Molecular carcinogenesis - 1 Jul 2001

Yeh C C, Lee C, Huang M C, Dahiya R

Abstract excerpt

Simian virus 40 large T antigen (SVLTAg) has been used to immortalize cells; however, the mechanism leading to immortalization is still unclear. We hypothesize that DNA mismatch repair (MMR) activity is important during SVLTAg-induced immortalization. To test this hypothesis, we used the SVLTAg-immortalized cell line BPH-1 derived from human benign prostate epithelial cells to analyze MMR activity and the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Polyomavirus Transforming
Share to Azacitidine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Decitabine

Share to Mismatch Repair Endonuclease PMS2

Share to MutL Proteins

Share to MutS Homolog 3 Protein

Share to Nucleic Acid Heteroduplexes

Share to Prostate

Source

Identifiers

PMID: 11479923
DOI: 10.1002/mc.1049

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of mismatch repair activity in simian virus 40 large T antigen-immortalized BPH-1 human prostatic epithelial cell line.PMID 11479923Read ↗

A study of molecular signals deregulating mismatch repair genes in prostate cancer compared to benign prostatic hyperplasia.Semantic proximity Read ↗

Alterations in PMS2, MSH2 and MLH1 expression in human prostate cancer.Semantic proximity Read ↗

Defects of DNA mismatch repair in human prostate cancer.Semantic proximity Read ↗

Gene expression profile and mutational analysis of DNA mismatch repair genes in carcinoma prostate in Indian population.Semantic proximity Read ↗

Loss of DNA mismatch repair proteins in prostate cancerSemantic proximity Read ↗

Polymorphisms of MLH1 in benign prostatic hyperplasia and sporadic prostate cancer.Semantic proximity Read ↗

Reduced Expression of Mismatch Repair Genes MSH6/MSH2 Directly Promotes Pituitary Tumor Growth via the ATR–Chk1 PathwaySemantic proximity Read ↗

Microsatellite instability in human prostate cancer.Semantic proximity Read ↗

Mutations in mismatch repair genes are involved in the neoplastic transformation of human breast epithelial cells.Semantic proximity Read ↗

The mismatch repair gene hMSH2 is mutated in the prostate cancer cell line LNCaP.Semantic proximity Read ↗

High frequency of mutator phenotype in human prostatic adenocarcinoma.Semantic proximity Read ↗

Truncation of the mismatch repair protein PMS2 during the neoplastic transformation of human breast epithelial cells in vitro.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.