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Article

Defects of DNA mismatch repair in human prostate cancer.

Cancer research - 15 May 2001

Chen Y, Wang J, Fraig M M, Metcalf J, Turner W R, Bissada N K, Watson D K, Schweinfest C W

Abstract excerpt

Loss of mismatch repair (MMR) function leads to the accumulation of errors that normally occur during DNA replication, resulting in genetic instability. Germ-line mutations of MMR genes in the patients with hereditary nonpolyposis colorectal cancer lead to inactivation of MMR protein functions, and the defects of MMR are well correlated to the high rate of microsatellite instability in their tumors. Previous...

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Share to Adenosine Triphosphatases
Share to Base Pair Mismatch
Share to Colorectal Neoplasms, Hereditary Nonpolyposis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mismatch Repair Endonuclease PMS2

Share to MutL Protein Homolog 1

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Source

Identifiers

PMID: 11358834

Genes

PMS1
MLH1
MSH2
PMS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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