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Loss of DNA mismatch repair proteins in prostate cancer

1 May 2020

Abstract excerpt

Recent studies have suggested an increased risk of prostate cancer in men with Lynch syndrome driven by germline mutations in mismatch repair (MMR) genes. However, the incidence and clinical implication of MMR deficiency in sporadic prostate cancers remain poorly understood. We immunohistochemically stained for MLH1, MSH2, MSH6, and PMS2 in a set of tissue microarray consisting of 220 radical prostatectomy...

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PMID: 32384491
DOI: 10.1097/md.0000000000020124

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