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Reduced Expression of Mismatch Repair Genes MSH6/MSH2 Directly Promotes Pituitary Tumor Growth via the ATR–Chk1 Pathway

12 Jan 2018

Abstract excerpt

Context: The mechanisms of pituitary adenoma (PA) pathogenesis and proliferation remain largely unknown. Objectives: To clarify the role of mismatch repair (MMR) genes in the molecular mechanism of PA proliferation. Design: We performed quantitative analyses by real-time polymerase chain reaction and immunohistochemistry to detect MMR gene and protein expression in human PAs (n = 47). We also performed...

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PMID: 29342268
DOI: 10.1210/jc.2017-02332

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