Article
Polymorphisms of MLH1 in benign prostatic hyperplasia and sporadic prostate cancer.
Biochemical and biophysical research communications - 12 Jun 2009
Tanaka Yuichiro, Zaman Mohd S, Majid Shahana, Liu Jan, Kawakami Kazumori, Shiina Hiroaki, Tokizane Takashi, Dahiya Angela V, Sen Saunak, Nakajima Koichi
Abstract excerpt
Mismatch repair is one of several DNA repair pathways of which defects may lead to cancer. We hypothesize that polymorphisms of the MLH1 gene can be a risk factor for benign prostatic hyperplasia (BPH) and prostate cancer. The genetic distribution of MLH1 polymorphisms that lead to amino acid changes at codons 132, 219, 384, and 723 were analyzed in BPH and sporadic prostate cancer patients, and compared to...
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