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Article

Alterations in PMS2, MSH2 and MLH1 expression in human prostate cancer.

International journal of oncology - 1 May 2003

Chen Yian, Wang Jiansong, Fraig Mostafa M, Henderson Kelly, Bissada Nabil K, Watson Dennis K, Schweinfest Clifford W

Abstract excerpt

DNA mismatch repair (MMR) is involved in the post-replication correction of errors due to misincorporated nucleotides or DNA slippage during DNA synthesis. We previously reported the reduction or loss of MMR protein expression in human prostate cancer cell lines and some primary tumors. In the present report, we further demonstrate the involvement of defects of MMR in the pathogenesis of prostate cancer....

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Topics

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Share to Adaptor Proteins, Signal Transducing
Share to Adenosine Triphosphatases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Base Pair Mismatch

Share to DNA Repair Enzymes

Share to Mismatch Repair Endonuclease PMS2

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Share to Prostatic Neoplasms

Source

Identifiers

PMID: 12684669

Genes

PMS2
MLH1
MSH2
BAX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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