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Article

Mutations in mismatch repair genes are involved in the neoplastic transformation of human breast epithelial cells.

International journal of oncology - 1 Aug 2003

Balogh Gabriela A, Russo Irma H, Russo Jose

Abstract excerpt

Mismatch repair (MMR) genes play a fundamental role in the correction of replication errors, leading to cancer development when mutated. In order to test the hypothesis that the MMR system was compromised in the initiation and progression of breast cancer, we used an in vitro-in vivo model for analyzing the mRNA levels of the MMR genes hMLH1, hMSH2, hPMS1, hPMS2 and hMSH6. MCF-10F, immortalized human breast...

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Identifiers

PMID: 12851690

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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