Article
Stimulation of mitogenic pathways through kinase-impaired mutants of the epidermal growth factor receptor.
Experimental cell research - 15 Aug 2001
Ewald J A, Coker K J, Price J O, Staros J V, Guyer C A
Abstract excerpt
Two residues have been shown to be critical for the kinase activity of the receptor for epidermal growth factor (EGF): lysine-721, which functions in the binding of ATP by correctly positioning the gamma-phosphate for phosphoryl transfer, and aspartate-813, which functions as the catalytic base of the kinase. Mutation of either of these two residues has been shown to disrupt kinase activity of the receptor....
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