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Article

Anti-oncogenic activity of signalling-defective epidermal growth factor receptor mutants.

Molecular and cellular biology - 1 Feb 1992

Redemann N, Holzmann B, von Rüden T, Wagner E F, Schlessinger J, Ullrich A

Abstract excerpt

Overexpression and autocrine activation of the epidermal growth factor receptor (EGF-R) cause transformation of cultured cells and correlate with tumor progression in cancer patients. Dimerization and transphosphorylation are crucial events in the process by which receptors with tyrosine kinase activity generate normal and transforming cellular signals. Interruption of this process by inactive receptor mutants...

Topics

3T3 Cells
Animals
DNA Mutational Analysis
DNA, Recombinant
Epidermal Growth Factor
ErbB Receptors
Gene Expression Regulation, Neoplastic
Genes, Tumor Suppressor
Genetic Vectors
Mice
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oncogene Proteins v-erbB

Phosphorylation

Retroviridae

Retroviridae Proteins, Oncogenic

Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 1346334
DOI: 10.1128/mcb.12.2.491-498.1992
PMCID: PMC364201

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1346334-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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