Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phosphorylation of the activation loop tyrosine 823 in c-Kit is crucial for cell survival and proliferation.

The Journal of biological chemistry - 2 Aug 2013

Agarwal Shruti, Kazi Julhash U, Rönnstrand Lars

Abstract excerpt

The receptor tyrosine kinase c-Kit, also known as the stem cell factor receptor, plays a key role in several developmental processes. Activating mutations in c-Kit lead to alteration of these cellular processes and have been implicated in many human cancers such as gastrointestinal stromal tumors...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Survival
Share to Chlorocebus aethiops
Share to COS Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Extracellular Signal-Regulated MAP Kinases

Share to Proto-Oncogene Proteins c-akt

Share to Proto-Oncogene Proteins c-kit

Share to Tyrosine

Share to Ubiquitination

Source

Open in PubMed Open full text

Identifiers

PMID: 23803604
DOI: 10.1074/jbc.M113.474072
PMCID: PMC3829335

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23803604-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phosphorylation of the activation loop tyrosine 823 in c-Kit is crucial for cell survival and proliferation.PMID 23803604Read ↗

Grb2 mediates negative regulation of stem cell factor receptor/c-Kit signaling by recruitment of Cbl.Semantic proximity Read ↗

Direct binding of Cbl to Tyr568 and Tyr936 of the stem cell factor receptor/c-Kit is required for ligand-induced ubiquitination, internalization and degradation.Semantic proximity Read ↗

The D816V mutation of c-Kit circumvents a requirement for Src family kinases in c-Kit signal transduction.Semantic proximity Read ↗

SRC-like adaptor protein 2 (SLAP2) is a negative regulator of KIT-D816V-mediated oncogenic transformation.Semantic proximity Read ↗

Stem Cell Factor Receptor/c-Kit: From Basic Science to Clinical ImplicationsSemantic proximity Read ↗

Oncogenic mutation in the Kit receptor tyrosine kinase alters substrate specificity and induces degradation of the protein tyrosine phosphatase SHP-1.Semantic proximity Read ↗

A change in structural integrity of c-Kit mutant D816V causes constitutive signaling.Semantic proximity Read ↗

Role of intracellular tyrosines in activating KIT-induced myeloproliferative disease.Semantic proximity Read ↗

KIT D816V is dimerization-independent and activates downstream pathways frequently perturbed in mastocytosis.Semantic proximity Read ↗

Tyrosine kinase mutations in human cancer.Semantic proximity Read ↗

C-KIT signaling in cancer treatment.Semantic proximity Read ↗

Tyrosine 842 in the activation loop is required for full transformation by the oncogenic mutant FLT3-ITD.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.