Article
Activation of the Ras/mitogen-activated protein kinase pathway by kinase-defective epidermal growth factor receptors results in cell survival but not proliferation.
Molecular and cellular biology - 1 Dec 1998
Walker F, Kato A, Gonez L J, Hibbs M L, Pouliot N, Levitzki A, Burgess A W
Abstract excerpt
Signalling by the epidermal growth factor (EGF) receptor (EGFR) has been studied intensively, but for most cell types the analysis is complicated by the fact that EGFR not only homodimerizes but can also form heterodimers with other EGFR family members. Heterodimerization is a particular problem...
Topics
- Adaptor Proteins, Signal Transducing
- Adaptor Proteins, Vesicular Transport
- Animals
- Calcium-Calmodulin-Dependent Protein Kinases
- Cell Division
- Cell Line
- Cell Survival
- Enzyme Activation
- Enzyme Inhibitors
- Epidermal Growth Factor
- ErbB Receptors
- GRB2 Adaptor Protein
- Guanosine Triphosphate