Article
Activation of the Ras/mitogen-activated protein kinase pathway by kinase-defective epidermal growth factor receptors results in cell survival but not proliferation.
Molecular and cellular biology - 1 Dec 1998
Walker F, Kato A, Gonez L J, Hibbs M L, Pouliot N, Levitzki A, Burgess A W
Abstract excerpt
Signalling by the epidermal growth factor (EGF) receptor (EGFR) has been studied intensively, but for most cell types the analysis is complicated by the fact that EGFR not only homodimerizes but can also form heterodimers with other EGFR family members. Heterodimerization is a particular problem in the study of EGFR mutants, where the true phenotype of the mutants is confounded by the contribution of the...
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