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Article

A differential requirement for the COOH-terminal region of the epidermal growth factor (EGF) receptor in amphiregulin and EGF mitogenic signaling.

The Journal of biological chemistry - 26 Mar 1999

Wong L, Deb T B, Thompson S A, Wells A, Johnson G R

Abstract excerpt

The epidermal growth factor receptor (EGFR) mediates the actions of a family of bioactive peptides that include epidermal growth factor (EGF) and amphiregulin (AR). Here we have studied AR and EGF mitogenic signaling in EGFR-devoid NR6 fibroblasts that ectopically express either wild type EGFR (WT) or a truncated EGFR that lacks the three major sites of autophosphorylation (c'1000). COOH-terminal truncation of...

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Identifiers

PMID: 10085134
DOI: 10.1074/jbc.274.13.8900

Genes

EGF
EGFR
GRB2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

A differential requirement for the COOH-terminal region of the epidermal growth factor (EGF) receptor in amphiregulin and EGF mitogenic signaling.PMID 10085134Read ↗

A functional screen for genes inducing epidermal growth factor autonomy of human mammary epithelial cells confirms the role of amphiregulin.Semantic proximity Read ↗

Cell and molecular biology of epidermal growth factor receptor.Semantic proximity Read ↗

Mutations in the polybasic juxtamembrane sequence of both plasma membrane- and endoplasmic reticulum-localized epidermal growth factor receptors confer ligand-independent cell transformation.Semantic proximity Read ↗

Erbb4 and its isoforms: selective regulation of growth factor responses by naturally occurring receptor variants.Semantic proximity Read ↗

Epidermal growth factor receptor cytoplasmic domain mutations trigger ligand-independent transformation.Semantic proximity Read ↗

Regulation of EGF receptor expression and function.Semantic proximity Read ↗

Analysis of deletions of the carboxyl terminus of the epidermal growth factor receptor reveals self-phosphorylation at tyrosine 992 and enhanced in vivo tyrosine phosphorylation of cell substrates.Semantic proximity Read ↗

Anti-oncogenic activity of signalling-defective epidermal growth factor receptor mutants.Semantic proximity Read ↗

Activation of the Ras/mitogen-activated protein kinase pathway by kinase-defective epidermal growth factor receptors results in cell survival but not proliferation.Semantic proximity Read ↗

Ligand-independent oncogenic transformation by the EGF receptor requires kinase domain catalytic activity.Semantic proximity Read ↗

Epidermal growth factor and membrane trafficking. EGF receptor activation of endocytosis requires Rab5a.Semantic proximity Read ↗

Stimulation of mitogenic pathways through kinase-impaired mutants of the epidermal growth factor receptor.Semantic proximity Read ↗

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