Article
Biochemical characterization of mutant EGF receptors expressed in the hemopoietic cell line BaF/3.
Growth factors (Chur, Switzerland) - 1 Jan 1998
Walker F, Hibbs M L, Zhang H H, Gonez L J, Burgess A W
Abstract excerpt
The Epidermal Growth Factor (EGF) receptor appears to require a fully active tyrosine kinase domain to transmit mitogenic signals. However, waved-2 mice carrying a mutation in the alpha-helix C of their EGF-R, which abolishes tyrosine kinase activity, only display a mild phenotype and are fully v...
Topics
- Adenosine Triphosphate
- Amino Acid Substitution
- Animals
- B-Lymphocytes
- Binding Sites
- Cell Membrane
- Endocytosis
- Epidermal Growth Factor
- ErbB Receptors
- Flow Cytometry
- Humans
- Kinetics
- Ligands
- Mice
- Models, Molecular
- Mutation
- Phosphorylation
- Phosphotyrosine