Article
Role of threonine residues in regulation of the epidermal growth factor receptor by protein kinase C and mitogen-activated protein kinase.
The Journal of biological chemistry - 25 Jul 1993
Morrison P, Takishima K, Rosner M R
Abstract excerpt
Epidermal growth factor (EGF) receptor tyrosine kinase activity is down-regulated by a number of growth-modulating agents that activate protein kinase C and/or mitogen-activated protein (MAP) kinases. Although the mechanism is unclear, it has been hypothesized that phosphorylation of specific thr...
Topics
- Animals
- CHO Cells
- Cloning, Molecular
- Cricetinae
- Epidermal Growth Factor
- ErbB Receptors
- Mitogen-Activated Protein Kinase 1
- Mutation
- Peptide Mapping
- Phorbol 12,13-Dibutyrate
- Phosphorylation
- Protein Kinase C
- Protein Serine-Threonine Kinases
- Protein-Tyrosine Kinases
- Threonine
- Transfection