Article
Cilia propel the embryo in the right direction.
American journal of medical genetics - 15 Jul 2001
Brueckner M
Abstract excerpt
Cilia have long been suspected to play a role in the determination of left-right asymmetry. Humans with the dominantly inherited condition Kartagener syndrome have defective cilia and a 50% incidence of mirror-image positioning of their organs (situs inversus). Analysis of mouse mutations affecting ciliary biogenesis and motility has demonstrated that the molecular motors kinesin and dynein are required to...
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