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Dynein axonemal intermediate chain 2 is required for formation of the left-right body axis and kidney in medaka.

Developmental biology - 1 Nov 2010

Nagao Yusuke, Cheng Jinglei, Kamura Keiichiro, Seki Ryoko, Maeda Aya, Nihei Daichi, Koshida Sumito, Wakamatsu Yuko, Fujimoto Toyoshi, Hibi Masahiko, Hashimoto Hisashi

Abstract excerpt

Ciliary defects lead to various diseases, such as primary ciliary dyskinesia (PCD) and polycystic kidney disease (PKD). We isolated a medaka mutant mii, which exhibits defects in the left-right (LR) polarity of organs, and found that mii encodes dynein axonemal intermediate chain 2a (dnai2a). Ortholog mutations were recently reported to cause PCD in humans. mii mutant embryos exhibited loss of nodal flow in...

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PMID: 20707998
DOI: 10.1016/j.ydbio.2010.08.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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