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A Conserved Domain of <i>Cfap298</i> Governs Left-Right Symmetry Breaking in Vertebrates

2025-05-17

Abstract excerpt

Cfap298 is a highly conserved gene required for ciliary motility and dynein arm assembly. It plays a known role in Left-Right (LR) patterning in zebrafish and is linked to human ciliopathies. Here we describe a new Cfap298 mutant allele, Cfap298 Δ3aa , which selectively interferes with LR axis establishment in mice. Mutant embryos display a range of laterality defects including situs solitus , situs inversus...

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Identifiers and source

Literature Corpus work
1454ce60-f8b7-5ac2-a683-a041f3a77748
DOI
10.1101/2025.05.16.654593
Open publication

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A Conserved Domain of <i>Cfap298</i> Governs Left-Right Symmetry Breaking in VertebratesDOI 10.1101/2025.05.16.654593
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