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Article

Pkd1l1 establishes left-right asymmetry and physically interacts with Pkd2.

Development (Cambridge, England) - 1 Mar 2011

Field Sarah, Riley Kerry-Lyn, Grimes Daniel T, Hilton Helen, Simon Michelle, Powles-Glover Nicola, Siggers Pam, Bogani Debora, Greenfield Andy, Norris Dominic P

Abstract excerpt

In mammals, left-right (L-R) asymmetry is established by posteriorly oriented cilia driving a leftwards laminar flow in the embryonic node, thereby activating asymmetric gene expression. The two-cilia hypothesis argues that immotile cilia detect and respond to this flow through a Pkd2-mediated mechanism; a putative sensory partner protein has, however, remained unidentified. We have identified the Pkd1-related...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21307093
DOI: 10.1242/dev.058149
PMCID: PMC3042869

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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