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Article

A conserved domain of Cfap298 governs left-right symmetry breaking in vertebrates.

Journal of cell science - 15 Oct 2025

Cortez Marvin, Young Cullen B, Little Katherine A, Grimes Daniel T, Devenport Danelle, Burdine Rebecca D

Abstract excerpt

Cfap298 is a highly conserved gene required for ciliary motility and dynein arm assembly, with known roles in left-right (LR) patterning in zebrafish and links to human ciliopathies. Here, we describe a Cfap298 mutant allele, Cfap298ΔΔS, which selectively disrupts LR axis establishment in mice. Mutant embryos display organ laterality defects and abnormal Nodal, Pitx2 and Lefty1 expression, consistent with an...

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Share to Zebrafish
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40955177
DOI: 10.1242/jcs.264129
PMCID: PMC12633728

Genes

CELSR1
CFAP298

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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