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Article

Two rotating cilia in the node cavity are sufficient to break left-right symmetry in the mouse embryo.

Nature communications - 10 Jan 2012

Shinohara Kyosuke, Kawasumi Aiko, Takamatsu Atsuko, Yoshiba Satoko, Botilde Yanick, Motoyama Noboru, Reith Walter, Durand Bénédicte, Shiratori Hidetaka, Hamada Hiroshi

Abstract excerpt

Determination of left-right asymmetry in mouse embryos is achieved by a leftward fluid flow (nodal flow) in the node cavity that is generated by clockwise rotational movement of 200-300 cilia in the node. The precise action of nodal flow and how much flow input is required for the robust read-out of left-right determination remains unknown. Here we show that a local leftward flow generated by as few as two...

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PMID: 22233632
DOI: 10.1038/ncomms1624

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Two rotating cilia in the node cavity are sufficient to break left-right symmetry in the mouse embryo.PMID 22233632Read ↗

Simulations of particle tracking in the oligociliated mouse node and implications for left-right symmetry breaking mechanicsSemantic proximity Read ↗

Establishment of left-right asymmetry in vertebrate development: the node in mouse embryos.Semantic proximity Read ↗

Wnt and Nodal asymmetries stratify mouse laterality phenotypes in the absence of node flow.Semantic proximity Read ↗

Meteorins regulate the formation of the left-right organizer and the establishment of vertebrate body asymmetrySemantic proximity Read ↗

Cilia propel the embryo in the right direction.Semantic proximity Read ↗

Cilia at the node of mouse embryos sense fluid flow for left-right determination via Pkd2.Semantic proximity Read ↗

Two populations of node monocilia initiate left-right asymmetry in the mouse.Semantic proximity Read ↗

Mechanism for generation of left isomerism in Ccdc40 mutant embryos.Semantic proximity Read ↗

Fluid extraction from the left-right organizer uncovers mechanical properties needed for symmetry breakingSemantic proximity Read ↗

Planar cell polarity breaks bilateral symmetry by controlling ciliary positioning.Semantic proximity Read ↗

Pkd1l1 establishes left-right asymmetry and physically interacts with Pkd2.Semantic proximity Read ↗

A mutation in the zebrafish Na,K-ATPase subunit atp1a1a.1 provides genetic evidence that the sodium potassium pump contributes to left-right asymmetry downstream or in parallel to nodal flow.Semantic proximity Read ↗

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