Article
Situs inversus and embryonic ciliary morphogenesis defects in mouse mutants lacking the KIF3A subunit of kinesin-II.
Proceedings of the National Academy of Sciences of the United States of America - 27 Apr 1999
Marszalek J R, Ruiz-Lozano P, Roberts E, Chien K R, Goldstein L S
Abstract excerpt
The embryonic cellular events that set the asymmetry of the genetic control circuit controlling left-right (L-R) axis determination in mammals are poorly understood. New insight into this problem was obtained by analyzing mouse mutants lacking the KIF3A motor subunit of the kinesin-II motor complex. Embryos lacking KIF3A die at 10 days postcoitum, exhibit randomized establishment of L-R asymmetry, and display...
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