Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeted deletion of the ATP binding domain of left-right dynein confirms its role in specifying development of left-right asymmetries.

Development (Cambridge, England) - 1 Dec 1999

Supp D M, Brueckner M, Kuehn M R, Witte D P, Lowe L A, McGrath J, Corrales J, Potter S S

Abstract excerpt

Vertebrates develop distinct asymmetries along the left-right axis, which are consistently aligned with the anteroposterior and dorsoventral axes. The mechanisms that direct this handed development of left-right asymmetries have been elusive, but recent studies of mutations that affect left-right development have shed light on the molecules involved. One molecule implicated in left-right specification is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Axonemal Dyneins
Share to Body Patterning

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dyneins

Share to Functional Laterality

Share to Nervous System

Share to Sequence Analysis

Source

Open in PubMed Open full text

Identifiers

PMID: 10556073
DOI: 10.1242/dev.126.23.5495
PMCID: PMC1797880

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeted deletion of the ATP binding domain of left-right dynein confirms its role in specifying development of left-right asymmetries.PMID 10556073Read ↗

Mutation of an axonemal dynein affects left-right asymmetry in inversus viscerum mice.Semantic proximity Read ↗

Formation and malformation of the vertebrate left-right axis.Semantic proximity Read ↗

An unconventional myosin in Drosophila reverses the default handedness in visceral organs.Semantic proximity Read ↗

Cilia propel the embryo in the right direction.Semantic proximity Read ↗

Establishment of left-right asymmetry in vertebrates: genetically distinct steps are involved.Semantic proximity Read ↗

Targeted deletion of the novel cytoplasmic dynein mD2LIC disrupts the embryonic organiser, formation of the body axes and specification of ventral cell fates.Semantic proximity Read ↗

Handed asymmetry in the mouse: understanding how things go right (or left) by studying how they go wrong.Semantic proximity Read ↗

No turning, a mouse mutation causing left-right and axial patterning defects.Semantic proximity Read ↗

Establishment of left-right asymmetry in vertebrate development: the node in mouse embryos.Semantic proximity Read ↗

Pkd1l1 establishes left-right asymmetry and physically interacts with Pkd2.Semantic proximity Read ↗

Two populations of node monocilia initiate left-right asymmetry in the mouse.Semantic proximity Read ↗

Type ID unconventional myosin controls left-right asymmetry in Drosophila.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.