Germline E-cadherin gene mutations: is prophylactic total gastrectomy indicated?

doi:10.1002/1097-0142(20010701)92:1<181::aid-cncr1307>3.0.co;2-j

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Article

Germline E-cadherin gene mutations: is prophylactic total gastrectomy indicated?

Cancer - 1 Jul 2001

Chun Y S, Lindor N M, Smyrk T C, Petersen B T, Burgart L J, Guilford P J, Donohue J H

Abstract excerpt

BACKGROUND: The CDH1 gene encodes E-cadherin, an epithelial cell adhesion molecule. Germline CDH1 mutations recently were identified in families with hereditary diffuse gastric carcinoma in a pattern suggestive of autosomal dominant inheritance with incomplete penetrance. METHODS: The proband was...

Topics

Adult
Cadherins
Female
Gastrectomy
Genetic Predisposition to Disease
Germ-Line Mutation
Humans
Male
Middle Aged
Primary Prevention
Stomach Neoplasms

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