Article
A prospective study of total gastrectomy for CDH1-positive hereditary diffuse gastric cancer.
Annals of surgical oncology - 1 Sept 2011
Chen Yijun, Kingham Kerry, Ford James M, Rosing James, Van Dam Jacques, Jeffrey R Brooke, Longacre Teri A, Chun Nicki, Kurian Allison, Norton Jeffrey A
Abstract excerpt
BACKGROUND: Hereditary diffuse gastric cancer (HDGC) is an autosomal dominant cancer syndrome. Up to 30% of families with HDGC have mutations in the E-cadherin gene, CDH1. The role of prophylactic versus therapeutic gastrectomy for HDGC was studied prospectively. METHODS: Eighteen consecutive patients with CDH1 mutations and positive family history were studied prospectively, including 13 without and 5 with...
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