Article
A prospective study of total gastrectomy for CDH1-positive hereditary diffuse gastric cancer.
Annals of surgical oncology - 1 Sept 2011
Chen Yijun, Kingham Kerry, Ford James M, Rosing James, Van Dam Jacques, Jeffrey R Brooke, Longacre Teri A, Chun Nicki, Kurian Allison, Norton Jeffrey A
Abstract excerpt
BACKGROUND: Hereditary diffuse gastric cancer (HDGC) is an autosomal dominant cancer syndrome. Up to 30% of families with HDGC have mutations in the E-cadherin gene, CDH1. The role of prophylactic versus therapeutic gastrectomy for HDGC was studied prospectively. METHODS: Eighteen consecutive pat...
Topics
- Adolescent
- Adult
- Aged
- Antigens, CD
- Cadherins
- Carcinoma, Signet Ring Cell
- Female
- Follow-Up Studies
- Gastrectomy
- Genetic Predisposition to Disease
- Humans
- Male
- Middle Aged
- Mutation
- Pedigree
- Prognosis
- Prospective Studies
- Stomach Neoplasms