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Article

Hereditary diffuse gastric cancer: prophylactic surgical oncology implications.

The Surgical clinics of North America - 1 Aug 2008

Lynch Henry T, Silva Edibaldo, Wirtzfeld Debrah, Hebbard Pamela, Lynch Jane, Huntsman David G

Abstract excerpt

Hereditary diffuse gastric cancer (HDGC) is an autosomal dominantly inherited syndrome attributed to mutations of the E-cadherin gene, CDH1. There is no proven effective screening for early HDGC, and symptomatic disease is almost universally fatal. The only available effective option for CDH1 carriers is prophylactic total gastrectomy, but the variable age of onset of HDGC and the reduced penetrance (about 70%)...

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Source

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Identifiers

PMID: 18672140
DOI: 10.1016/j.suc.2008.04.006
PMCID: PMC2561947

Genes

CDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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