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Article

Hereditary diffuse gastric cancer: diagnosis, genetic counseling, and prophylactic total gastrectomy.

Cancer - 15 Jun 2008

Lynch Henry T, Kaurah Pardeep, Wirtzfeld Debrah, Rubinstein Wendy S, Weissman Scott, Lynch Jane F, Grady William, Wiyrick Sara, Senz Janine, Huntsman David G

Abstract excerpt

BACKGROUND: A subset of patients with diffuse gastric cancer harbor deleterious cancer-causing germline mutations in the type 1 E-cadherin (epithelial) gene (CDH1), which predisposes to the autosomal dominantly inherited hereditary diffuse gastric cancer (HDGC) syndrome. These mutations are associated with a 70% life-time risk for diffuse gastric cancer (DGC) and an additional 40% risk for lobular breast cancer...

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Source

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Identifiers

PMID: 18442100
DOI: 10.1002/cncr.23501
PMCID: PMC2629639

Genes

CDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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CDH1 Gene and Hereditary Diffuse Gastric Cancer Syndrome: Molecular and Histological Alterations and Implications for Diagnosis And TreatmentSemantic proximity Read ↗

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