Article
Risk-reducing total gastrectomy for germline mutations in E-cadherin (CDH1): pathologic findings with clinical implications.
The American journal of surgical pathology - 1 Jun 2008
Rogers William M, Dobo Erika, Norton Jeffrey A, Van Dam Jacques, Jeffrey R Brooke, Huntsman David G, Kingham Kerry, Chun Nicki, Ford James M, Longacre Teri A
Abstract excerpt
Hereditary diffuse gastric cancer is a rare autosomal dominant cancer susceptibility syndrome caused by germline E-cadherin (CDH1) mutations in 40% of cases with a high degree of penetrance. Screening endoscopy has not been useful in identifying early cancer, in part owing to conflicting data con...
Topics
- Adult
- Aged
- Antigens, CD
- Cadherins
- Carcinoma, Signet Ring Cell
- Female
- Gastrectomy
- Genetic Predisposition to Disease
- Germ-Line Mutation
- Humans
- Male
- Middle Aged
- Risk Factors
- Stomach Neoplasms