Article
Risk-reducing total gastrectomy for germline mutations in E-cadherin (CDH1): pathologic findings with clinical implications.
The American journal of surgical pathology - 1 Jun 2008
Rogers William M, Dobo Erika, Norton Jeffrey A, Van Dam Jacques, Jeffrey R Brooke, Huntsman David G, Kingham Kerry, Chun Nicki, Ford James M, Longacre Teri A
Abstract excerpt
Hereditary diffuse gastric cancer is a rare autosomal dominant cancer susceptibility syndrome caused by germline E-cadherin (CDH1) mutations in 40% of cases with a high degree of penetrance. Screening endoscopy has not been useful in identifying early cancer, in part owing to conflicting data concerning site(s) of involvement in the stomach and the lack of endoscopically detectable pathology. Risk-reducing total...
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