Article
Prophylactic laparoscopic-assisted total gastrectomy for hereditary diffuse gastric cancer.
JSLS : Journal of the Society of Laparoendoscopic Surgeons - 1 Jan 2000
Francis Wesley P, Rodrigues Daniald M, Perez Nolan E, Lonardo Fulvio, Weaver Donald, Webber John D
Abstract excerpt
BACKGROUND: Ten percent of gastric cancer (GC) cases are familial, with one third resulting from a mutation in the tumor suppressor gene CDH1. Loss of this important structure can result in hereditary diffuse gastric cancer (HDGC), which carries a high mortality if early diagnosis is not made. Despite its clear genetic origin, optimal management of HDGC family members is controversial, as the utility and efficacy...
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