Article
Prophylactic total gastrectomy for familial gastric cancer.
Surgery - 1 Oct 2001
Lewis F R, Mellinger J D, Hayashi A, Lorelli D, Monaghan K G, Carneiro F, Huntsman D G, Jackson C E, Caldas C
Abstract excerpt
BACKGROUND: An autosomal dominant syndrome of diffuse gastric cancer has been reported with germline mutations in the E-cadherin (CDH1) gene and has been identified in approximately 14 families and 50 individuals worldwide. Penetrance of the gene is 70% to 80%, and the average age of onset of gastric cancer is 37 years. These characteristics have led to the consideration of prophylactic total gastrectomy in...
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