Article
Prophylactic gastrectomy for hereditary diffuse gastric cancer syndrome.
Journal of the American College of Surgeons - 1 Apr 2006
Newman Erika A, Mulholland Michael W
Abstract excerpt
BACKGROUND: Germline mutations in the E-cadherin gene, CDH1, were recently identified in families with hereditary diffuse gastric cancer. The efficacy of endoscopic surveillance by current methods is largely ineffective because most tumors spread diffusely. There has been little evidence that prophylactic gastrectomy should be performed in patients with the genetic mutation, and few data are available on the...
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