Article
Prophylactic total gastrectomy for hereditary diffuse gastric cancer. Review of the literature.
Surgical oncology - 1 Dec 2011
Mastoraki Aikaterini, Danias Nikolaos, Arkadopoulos Nikolaos, Sakorafas George, Vasiliou Pantelis, Smyrniotis Vasilios
Abstract excerpt
Hereditary diffuse gastric cancer (HDGC) is characterized as an autosomal dominant cancer susceptibility syndrome largely attributable to germline mutations and deletions in the gene encoding E-cadherin, CDH1. Mutation carriers have a more than 70% lifetime risk of developing DGC and an elevated probability of lobular breast cancer. The aim of this review was to evaluate the results of surgical treatment for HDGC...
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